What we do

Work packages

ACT-PREP’s work is organised into 24 formal work packages, grouped into 12 thematic areas to make them easier to navigate and understand. Each area has a lead institution and a plain-language summary of its focus.

Theme 1

Project Management & Monitoring

EDCTP Association WP1

Keeps the whole project on track: planning, timelines and responsibilities across all work packages, consortium communication, risk management, and compliance with Horizon Europe rules and the Grant Agreement, including reporting to the Global Health EDCTP3.

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Theme 2

Scientific Project Leadership

MakSPH WP2–WP4

Contributions from MUHAS, SNU and UCAD

Provides scientific governance for the whole project — strategic decision-making, quality assurance of deliverables, the data-management and access plans, dissemination and exploitation planning, monitoring and evaluation, sustainability, and the project website.

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Theme 3

Comprehensive Needs & Capacities Assessment

Africa CDC WP5

Co-led with UGHE and MakSPH

Systematically maps gaps, strengths and opportunities in clinical research and trials during public health emergencies — covering policy, ethics and regulatory readiness and resources — drawing on lessons from EDCTP1 & 2 to target capacity-building and equitable-access strategies.

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Theme 4

Surveillance, Diagnostics & Policy Foundations

MakSPH WP6

Co-led with UGHE

Advances Africa-led innovation and sustainable local financing for outbreak-triggered research, institutionalises a real-time digital platform for surveillance and early warning, and scales epidemic preparedness and response with One Health and community engagement at its core.

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Theme 5

Digital Acceleration, Training & Community Engagement

MakSPH WP7–WP8

Builds and scales epidemic-response capacity through One Health training short courses, an M&E framework, operationalising the 7-1-7 approach, digital toolkits for rapid deployment, AI-supported routine data, a database and network of EPR and clinical-trial researchers, and field-drill exercises.

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Theme 6

Clinical Research Capacity Building

IDRC WP9–WP11

Consolidates and expands clinical-trial capacity built under EDCTP1 & 2: scalable hybrid training, MOOCs and embedded fellowships across cadres and career stages; a training curriculum for clinical-trial monitors (CROs); community engagement; at least one ICH-compliant site; and a continent-wide outbreak research network.

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Theme 7

Recruitment of PhDs & Postdoctoral Researchers

Université de Kinshasa (KSPH) WP12

Co-led with MakSPH; contributions from KI, UCAD and SNU

Provides competitive PhD scholarships and postdoctoral fellowships in epidemic-related disciplines, embedding fellows within ongoing clinical trials with structured mentorship to build a sustainable, networked pipeline of research leaders.

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Theme 8

Leadership, Mentorship & Networking

Université de Kinshasa (KSPH) WP13–WP14

Develops mid-career and senior researchers through mentorship, research-administration and management training, supervision structures, and support to completion — producing peer-reviewed manuscripts and conference presentations from fellows' research.

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Theme 9

Strengthening Ethics, Regulatory & Pharmacovigilance Expertise

MUHAS WP15–WP17

Builds a robust, sustainable and regionally harmonised ecosystem for ethically sound, safe clinical research: assessment of ethics, regulatory and pharmacovigilance systems; outbreak-specific frameworks; digital tools for review bodies; learning exchanges and benchmarking visits; and trained professionals.

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Theme 10

Laboratory Infrastructure & Systems Strengthening

Ministry of Health – NHLDS (Uganda) WP18–WP20

Co-led with BNITM

Upgrades laboratory and surveillance infrastructure for high-consequence pathogens at strategic cross-border and epidemic-hotspot sites, implements quality-management systems, strengthens data management and workforce competency, and builds collaborative clinical-research frameworks. At least five laboratories upgraded.

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Theme 11

Dissemination, Outreach, Community Engagement & Knowledge Translation

Karolinska Institutet (KI) WP21–WP23

Co-led with Africa CDC and MakSPH

Fosters equitable partnerships and cross-sectoral collaboration, builds community trust in clinical trials, and turns research into policy and practice — via annual research showcases, a knowledge-translation strategy, research-to-policy newsletters, regional policy-dialogue events, and a repository of co-created decision tools.

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Theme 12

Grant Writing, National Health Research Systems & Technical Site Visits

EDCTP Association WP24

Strengthens the wider research system: an NHRS "Barometer" assessment, grant-writing workshops (Maputo and Dakar), standardised technical site-visit audit and reporting templates, site-visit reports, and networking meetings with the other EDCTP3 regional networks.

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